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This article provides an in-depth analysis of the COM class factory retrieval error 80040154 encountered when deploying C#.NET Windows services in Windows Server 2008 64-bit environments. Through case studies, it explores the root causes of 32-bit and 64-bit platform compatibility issues, focusing on the solution of setting project platform target to X86. Combined with COM interop principles and practical deployment experience, it offers comprehensive troubleshooting guidance, including registry configuration, DLL registration considerations, and cross-platform development best practices.