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This article provides an in-depth exploration of mainstream .NET profiling tools, focusing on the functional characteristics and application scenarios of JetBrains dotTrace, Redgate ANTS, EQATEC, and Microsoft CLR Profiler. Through detailed comparative evaluations, it reveals the advantages and limitations of each tool in performance and memory analysis, offering practical tool selection recommendations based on real-world development experience. The article also analyzes the working principles of .NET profilers from a technical architecture perspective, helping developers better understand and utilize these critical tools for application performance optimization.