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This article provides an in-depth analysis of the common error "A fatal error occurred. The required library hostfxr.dll could not be found" encountered during .NET Core application deployment. By examining the differences between framework-dependent and self-contained deployments, it details methods for configuring self-contained deployment in Visual Studio, including GUI settings and command-line publishing options. The article also discusses installing runtime environments as an alternative solution, offering practical code examples and deployment best practices to help developers ensure stable application execution across diverse environments.